ECP versus ruxolitinib in steroid-refractory chronic GVHD - a retrospective study by the EBMT transplant complications working party

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作者: Penack, Olaf;Peczynski, Christophe;Boreland, William;Lemaitre, Jessica;Reinhardt, H. Christian;...
通讯作者: Penack, O
作者机构: Charite Univ Med Berlin, Med Clin, Dept Haematol Oncol & Tumorimmunol, Berlin, Germany.
EBMT Transplant Complicat Working Party, Paris, France.
Sorbonne Univ, St Antoine Hosp, Dept Haematol, INSERM,EBMT Paris Study Off,UMR S 938, Paris, France.
Univ Hosp, Essen, Germany.
Pavlov Univ, RM Gorbacheva Res Inst, St Petersburg, Russia.
KingsCollege Hosp, London, England.
Univ Hosp Bonn, Dept Oncol Hematol Immuno Oncol & Rheumatol, Bonn, Germany.
Rigshosp, Copenhagen, Denmark.
Papanicolaou G Hosp, Thessaloniki, Greece.
Univ Barcelona, Hosp Clin Barcelona, Hematol Dept, Hematopoiet Stem Cell Unit, Barcelona, Spain.
Univ Cattolica Sacro Cuore Roma, Fdn Policlin Univ Gemelli IRCCS, Rome, Italy.
ASST Papa Giovanni XXIII, Bergamo, Italy.
Inst Cancerol Lucien Neuwirth, St Etienne, France.
Skane Univ Hosp Lund, Lund, Sweden.
Baskent Univ Hosp, Dept Hematol, Adana, Turkiye.
Univ Clin Ctr, Dept Hematol & Transplantol, Gdansk, Poland.
Med Univ Gdansk, Gdansk, Poland.
Univ Hosp Birmingham NHS Trust, Birmingham, England.
Med Univ Warsaw, Dept Hematol Oncol & Internal Med, Warsaw, Poland.
Univ Hosp Leuven, Dept Hematol, Leuven, Belgium.
Univ Leuven, KU Leuven, Dept Publ Hlth & Primary Care, ACCENT10, Leuven, Belgium.
Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpla, Hannover, Germany.
Univ Hosp Ctr Rijeka, Dept Haematol, Rijeka, Croatia.
通讯机构: Charite Univ Med Berlin, Med Clin, Dept Haematol Oncol & Tumorimmunol, Berlin, Germany.
EBMT Transplant Complicat Working Party, Paris, France.
语种: 英文
关键词: VERSUS-HOST-DISEASE,EXTRACORPOREAL PHOTOPHERESIS
期刊: Bone Marrow Transplantation
ISSN: 0268-3369
年: 2024
卷: 58
期: SUPPL-1
页码: 295-296
会议名称: 49th Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation
会议时间: APR 23-26, 2023
会议地点: ELECTR NETWORK
基金类别: Jose Carreras Leukamie-Stiftung [3 R/2019, 23 R/2021]; Deutsche Krebshilfe [70113519]; Deutsche Forschungsgemeinschaft [PE 1450/7-1, PE 1450/9-1, PE1450/10-1]; Stiftung Charite BIH [BIH_PRO_549]; Projekt DEAL
摘要: Ruxolitinib has become the new standard of care for steroid-refractory and steroid-dependent chronic GVHD (SR-cGVHD). Our aim was to collect comparative data between ruxolitinib and extracorporeal photophoresis (ECP). We asked EBMT centers if they were willing to provide detailed information on GVHD grading, -therapy, -dosing, -response and complications for each included patient. 31 centers responded positively and we included all patients between 1/2017-7/2019 treated with ECP or ruxolitinib for moderate or severe SR-cGVHD. We identified 84 and 57 patients with ECP and ruxolitinib, respectively. We performed multivariate analyses adjusted on grading and type of SR-cGVHD...

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