Diagnostic yield of postmortem brain examination following premortem brain biopsy for neoplastic and nonneoplastic disease
作者：
MacRae, Cassie B.;Grieco, Kristina C.;Solomon, Isaac H.
通讯作者：
Solomon, IH
作者机构：
Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA.
Harvard Med Sch, Boston, MA USA.
通讯机构：
Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA.
语种：
英文
关键词：
Autopsy,Brain Biopsy,Diagnostic yield,Postmortem,Quality improvement
期刊：
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
ISSN：
0022-3069
年：
2024
卷：
82
期：
6
页码：
584-585
会议名称：
99th Annual Meeting of the American-Association-of-Neuropathologists (AAN)
会议时间：
JUN 08-11, 2023
会议地点：
Monterey, CA
基金类别：
None declared.
摘要：
Medical autopsies have decreased in frequency due in part to advances in radiological techniques and increased availability of molecular and other ancillary testing. However, premortem diagnosis of CNS disease remains challenging; while similar to 90% of brain tumor biopsies are diagnostic, only 20%-70% of biopsies for presumed nonneoplastic disease result in a specific diagnosis. The added benefits of performing an autopsy following surgical brain biopsy are not well defined. A retrospective analysis was performed of patients who underwent brain biopsy and autopsy at Brigham and Women's Hospital from 2003 to 2022. A total of 135 cases were identified, including 95 (70%) ...
