作者：
Hirt, Julian;Janiaud, Perrine;Dueblin, Pascal;Nicoletti, Giovanni Jacopo;Dembowska, Kinga;...
通讯作者：
Hemkens, LG
作者机构：
Univ Hosp Basel, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Spitalstr 2, CH-4031 Basel, Switzerland.
Univ Basel, Spitalstr 2, CH-4031 Basel, Switzerland.
Univ Hosp Basel, Dept Clin Res, Basel, Switzerland.
Eastern Switzerland Univ Appl Sci, Dept Hlth, St Gallen, Switzerland.
Univ Basel, MSc Program Epidemiol, Swiss TPH, Basel, Switzerland.
通讯机构：
Univ Hosp Basel, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Spitalstr 2, CH-4031 Basel, Switzerland.
Univ Basel, Spitalstr 2, CH-4031 Basel, Switzerland.
语种：
英文
关键词：
Multiple sclerosis,pragmatic clinical trial,randomized controlled trial,routinely collected health data
期刊：
Multiple Sclerosis Journal
ISSN：
1352-4585
年：
2024
卷：
29
期：
SUPPL-3
页码：
378-379
会议名称：
9th Joint ECTRIMS-ACTRIMS meeting
会议时间：
OCT 11-13, 2023
会议地点：
Milan, ITALY
基金类别：
Swiss National Science Foundation [188675
摘要：
Background: Pragmatic trials are increasingly recognized for providing real-world evidence on treatment choices.Objective: The objective of this study is to investigate the use and characteristics of pragmatic trials in multiple sclerosis (MS).Methods: Systematic literature search and analysis of pragmatic trials on any intervention published up to 2022. The assessment of pragmatism with PRECIS-2 (PRagmatic Explanatory Continuum Indicator Summary-2) is performed.Results: We identified 48 pragmatic trials published 1967-2022 that included a median of 82 participants (interquartile range (IQR) = 42-160) to assess typically supportive care interventions (n = 41; 85%). Only s...
