作者：
Wang, Xinran;Chen, Ningxin;Cruz-Morales, Pablo;Zhong, Biming;Zhang, Yangming;...
通讯作者：
Keasling, Jay D.;Luo, XZ;Tang, XY;Keasling, JD
作者机构：
Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Ctr Synthet Biochem,Shenzhen Key Lab Intelligent M, Shenzhen, Peoples R China.
Tech Univ Denmark, Novo Nord Fdn Ctr Biosustainabil, Lyngby, Denmark.
Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan, Peoples R China.
Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai, Peoples R China.
Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai, Peoples R China.
Inst Chem Biol, Shenzhen Bay Lab, Shenzhen, Peoples R China.
Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA.
Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA.
Huazhong Univ Sci & Technol, Sch Pharm, Wuhan, Peoples R China.
Joint BioEnergy Inst, Emeryville, CA 94608 USA.
Lawrence Berkeley Natl Lab, Biol Syst & Engn Div, Berkeley, CA 94720 USA.
Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen Infrastruct Synthet Biol, Shenzhen, Peoples R China.
通讯机构：
Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Ctr Synthet Biochem,Shenzhen Key Lab Intelligent M, Shenzhen, Peoples R China.
Inst Chem Biol, Shenzhen Bay Lab, Shenzhen, Peoples R China.
Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA.
Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA.
Joint BioEnergy Inst, Emeryville, CA 94608 USA.
Lawrence Berkeley Natl Lab, Biol Syst & Engn Div, Berkeley, CA 94720 USA.
Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Shenzhen Infrastruct Synthet Biol, Shenzhen, Peoples R China.
语种：
英文
关键词：
PYRROLOQUINOLINE QUINONE,STREPTOMYCES,BIOGENESIS,COFACTOR
期刊：
Nature Metabolism
ISSN：
2522-5812
年：
2024
基金类别：
China Postdoctoral Science Foundation [2018YFA0903200]; National Key R&D Program of China [32071421, 32201203]; National Natural Science Foundation of China [JCYJ20220531100207017]; Shenzhen Science and Technology Program [31800023]; China Postdoctoral Science Foundation [D2301005]; Shenzhen Medical Research Fund [229100002]; Shenzhen Bay Scholar Fellowship [NNF20CC0035580]; Novo Nordisk Foundation
摘要：
Streptomyces has the largest repertoire of natural product biosynthetic gene clusters (BGCs), yet developing a universal engineering strategy for each Streptomyces species is challenging. Given that some Streptomyces species have larger BGC repertoires than others, we proposed that a set of genes co-evolved with BGCs to support biosynthetic proficiency must exist in those strains, and that their identification may provide universal strategies to improve the productivity of other strains. We show here that genes co-evolved with natural product BGCs in Streptomyces can be identified by phylogenomics analysis. Among the 597 genes that co-evolved with polyketide BGCs, 11 gene...
