作者：
Minjuan Li;Yangyi Zhang;Zheyuan Wu;Yuan Jiang;Ruoyao Sun;...
通讯作者：
Chongguang Yang;Xin Shen
作者机构：
School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s *
Division of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s *
Shanghai Institutes of Preventive Medicine, Shanghai, People’s *
Department of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, People’s *
Division of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s *
Shanghai Institutes of Preventive Medicine, Shanghai, People’s *
Division of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s *
Shanghai Institutes of Preventive Medicine, Shanghai, People’s *
School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s *
Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People’s *
Division of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s *
Shanghai Institutes of Preventive Medicine, Shanghai, People’s *
School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s *
School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s *
Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, People’s *
Division of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s *
Shanghai Institutes of Preventive Medicine, Shanghai, People’s *
Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People’s *
Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, People’s *
Nanshan District Center for Disease Control and Prevention, Shenzhen, People’s *
School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s *
Nanshan District Center for Disease Control and Prevention, Shenzhen, People’s *
Division of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s *
Shanghai Institutes of Preventive Medicine, Shanghai, People’s *
通讯机构：
School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Guangdong, People’s *
Nanshan District Center for Disease Control and Prevention, Shenzhen, People’s *
Division of TB and HIV/AIDS Prevention, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s *
Shanghai Institutes of Preventive Medicine, Shanghai, People’s *
语种：
英文
关键词：
Multidrug-resistant tuberculosis,fluoroquinolones resistance,whole-genome sequencing,drug resistance transmission,China
期刊：
Emerging Microbes & Infections
ISSN：
2222-1751
年：
2024
卷：
13
期：
1
页码：
2302837
基金类别：
This work was supported by the National Key Research and Development Program of China [grant number 2023YFC2307305], National Natural Science Foundation of China [grant number 81872679 and 82373650], Science and Technology Innovation Plan of Shanghai Science and Technology Commission [grant number21DZ2202400], Shanghai Municipal Health Commission [grant number 202340298], Shenzhen Nanshan district San-Ming project [grant number SZSM202103008], “Pearl River Talent Plan” Innovation and Entrepreneurship Team Project of Guangdong Province [grant number 2021ZT09Y544], Shanghai three-year (2023-2025) action plan to strengthen the public health system [grant number GWVI-11.1-05], and the Top Young Talents in Shanghai [X.S.].
摘要：
Fluoroquinolones (FQ) are essential for the treatment of multidrug-resistant tuberculosis (MDR-TB). The FQ resistance (FQ-R) rate in MDR-TB in China and its risk factors remain poorly understood. We conducted a retrospective, population-based genomic epidemiology study of MDR-TB patients in Shanghai, China, from 2009 to 2018. A genomic cluster was defined as strains with genetic distances ≤ 12 single nucleotide polymorphisms. The transmitted FQ-R was defined as the same FQ resistance-conferring mutations shared by ≥ 2 strains in a genomic cluster. We used multivariable logistic regression analysis to identify the risk factors for drug resistance. Among the total 850...
